Reduced stomach acidity affecting medication dissolution is known as which condition?

Reduced stomach acidity affecting medication dissolution is known as which condition?

• A. GERD
• B. Dyspepsia
• C. PUD
• D. Achlorhydria

Answer: (D)

Achlorhydria. When the stomach lacks acid, the environment needed to dissolve many oral medications is diminished, so dissolution and subsequent absorption can be delayed or incomplete. This is especially relevant in older adults, where reduced gastric acidity from aging or from chronic acid-suppressing therapy can affect drugs that rely on an acidic environment for proper dissolution (for example, certain iron preparations or calcium carbonate). Other conditions listed involve too much acid or general indigestion, not absence of acid, so they don’t explain reduced dissolution the way achlorhydria does.

Achlorhydria. When the stomach lacks acid, the environment needed to dissolve many oral medications is diminished, so dissolution and subsequent absorption can be delayed or incomplete. This is especially relevant in older adults, where reduced gastric acidity from aging or from chronic acid-suppressing therapy can affect drugs that rely on an acidic environment for proper dissolution (for example, certain iron preparations or calcium carbonate). Other conditions listed involve too much acid or general indigestion, not absence of acid, so they don’t explain reduced dissolution the way achlorhydria does.